Phenyl Isothiocyanate → HCID 18511674, compound

HRID 1370540Notes

Reaction equation

HRID 1370540 reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl.[CH3:12][NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH2:16][CH2:15]1.C(N(CC)CC)C>C(O)C>[F:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][CH2:24][O:23][CH2:22][CH2:21][CH2:20][N:17]2[CH2:16][CH2:15][CH:14]([N:13]([CH3:12])[C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[S:9])[CH2:19][CH2:18]2)=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 7673Phenyl IsothiocyanateHCID 8471TriethylamineHCID 18511649HCID 18511649, compound

Product 1

HCID 18511674HCID 18511674, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 736 mg (5.44 mmol) of phenyl isothiocyanate in 15 ml of ethanol is treated with 2 g (5.44 mmol) of the preceding hydrochloride 22.3 and then 1.51 ml (10.9 mmol) of triethylamine. After stirring for 1 h, the mixture is evaporated to dryness and treated as in Example 1.1 to give 1.88 g (Yd: 81%) of compound of formula 22.4:

Workup

  1. customthe mixture is evaporated to dryness
  2. additiontreated as in Example 1.1

Sources & evidence

ORD record
ord-c64e3f5c2e934e10ae27ec86e5706cc9
Source dataset
uspto-grants-2003_06
Patent number
US06583159B1

Reaction notes

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