Diisopropyl Ether → HCID 18752890, compound

HRID 1370587Notes

Reaction equation

HRID 1370587 reaction equation
[NH2:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:6][C:5]([Cl:13])=[CH:4][N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C(OC(C)C)(C)C>C(O)(C)C>[NH2:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:12])=[CH:6][C:5]([Cl:13])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 8083MorpholineHCID 18752895HCID 18752895, compound

Product 1

HCID 18752890HCID 18752890, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The title compound was prepared from (E)-3-(2-amino-5-chloro-3-pyridinyl)-2-propenoic acid and morpholine as a yellow solid following crystallisation from isopropyl alcohol and trituration with diisopropyl ether:

Sources & evidence

ORD record
ord-1d9f3d82c31b438cbf1d2b04dee3b631
Source dataset
uspto-grants-2003_06
Patent number
US06583162B1

Reaction notes

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