Hydrochloric Acid → HCID 57310240, compound

HRID 1370732Notes

Reaction equation

HRID 1370732 reaction equation
[C:1]([NH:4][C@H:5]([C:23]([NH:25]C1CCCCO1)=[O:24])[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8])(=[O:3])[CH3:2].Cl.[O:33]1CCOCC1>>[C:1]([NH:4][C@H:5]([C:23]([NH:25][OH:33])=[O:24])[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86759031HCID 86759031, compound

Product 1

HCID 57310240HCID 57310240, compoundYield 32%

Procedure

The product from Example 9f (1.0 mmol, 450 mg) was dissolved in dioxane (5 mL). Six normal HCl (0.5 mL) was added, and the mixture was stirred one hour. Concentration followed by chromatography afforded the title compound as a glass (120 mg, 32%). MS MH+ calcd. for C17H18N2O6S 378, found 379.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-c0316885b1e04e1c8a135a92f05988b1
Source dataset
uspto-grants-2003_06
Patent number
US06583299B1

Reaction notes

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