HCID 131723933, compound → HCID 70016103, compound

HRID 1370735Notes

Reaction equation

HRID 1370735 reaction equation
[C:1]([NH:4][C@H:5]([C:17]([O:19]C)=[O:18])[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)(=[O:9])=[O:8])(=[O:3])[CH3:2]>C(O)(=O)C.Cl>[C:1]([NH:4][C@H:5]([C:17]([OH:19])=[O:18])[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)(=[O:8])=[O:9])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 131723933HCID 131723933, compound

Product 1

HCID 70016103HCID 70016103, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

A solution of the title compound of Example 11a (17.9 g, 59.0 mmol) in glacial acetic acid (135 mL) and concentrated HCl (135 mL), was heated to 7 degrees C. for 2 hours. The solution was concentrated under a stream of N2 to yield the title compound as a white solid (17.0 g, quant. yield): MS MH+ calcd. for C11H12NO5SF: 290, found 290. HRMS calc. for C11H13NO5SF: 290.0499, found: 290.0520.

Workup

  1. concentrationThe solution was concentrated under a stream of N2

Sources & evidence

ORD record
ord-f1589fde7d5e409b8cd06845c1ec40c0
Source dataset
uspto-grants-2003_06
Patent number
US06583299B1

Reaction notes

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