反应详情

温度

40 °C

4′-methanesulfonyl-biphenyl-3,4-diol (30 mg) and potassium carbonate (38 mg) were dissolved in methylethylketone. Afterward, benzylbromide (60 mg) and tetrabutylammoniumiodide (2-3 mg) were added one after another and heated for 24 hours at 40° C. After filtering just potassium carbonate, the residue was separated through a silica gel attributed chromatography (an eluting agent: ethylacetate/n-hexane=1/1, v/v). As a result, the present compound (42 mg, productive yield 85%) was obtained.

1. filtrationAfter filtering just potassium carbonate
2. customthe residue was separated through a silica gel
3. customAs a result, the present compound (42 mg, productive yield 85%) was obtained