反应详情

The product from Example 33A (0.1 g, 26 mmoles) in DMF (0.65 mL) was treated with sodium hydride (0.011 g, 0.26 mmoles). After 10 minutes, the reaction mixture was treated with cinnamyl bromide (0.10 g, 0.52 mmoles) and shaken overnight. The mixture was diluted with diethyl ether (50 mL), washed with saturated ammonium chloride (50 mL) and water (2×50 mL), brine (50 mL), dried (Na2SO4), filtered and the filtrate concentrated under reduced pressure to provide the title compound which was used in the next step without further purification.

1. washwashed with saturated ammonium chloride (50 mL) and water (2×50 mL), brine (50 mL)
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. concentrationthe filtrate concentrated under reduced pressure