Hydrochloric Acid → HCID 18512283, compound

HRID 1370889Notes

Reaction equation

HRID 1370889 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:48]=[CH:47][C:25]([O:26][C:27]2[CH:28]=[C:29]([CH:44]=[CH:45][CH:46]=2)[O:30][CH2:31][CH:32]2[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33]2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>O1CCOCC1>[CH2:1]([N:8]([CH2:21][C:22]1[CH:48]=[CH:47][C:25]([O:26][C:27]2[CH:46]=[CH:45][CH:44]=[C:29]([O:30][CH2:31][CH:32]3[CH2:36][CH2:35][NH:34][CH2:33]3)[CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18511972HCID 18511972, compound

Product 1

HCID 18512283HCID 18512283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 93C (0.108 g, 0.161 mmoles) was treated with 4 N HCl (2.0 mL/8.00 mmoles) in dioxane and stirred at room temperature for one hour. Reaction quenched with saturated NaHCO3 and extracted with CH2Cl2. Extracts dried (Na2SO4), filtered, and the filtrate concentrated under reduced pressure to provide the title compound with no further purification.

Workup

  1. customReaction
  2. customquenched with saturated NaHCO3
  3. extractionextracted with CH2Cl2
  4. dry with materialExtracts dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-15324d99ce0c49f2b6c11f9b389f2d09
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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