HCID 18510234, compound → HCID 18510257, compound

HRID 1371027Notes

Reaction equation

HRID 1371027 reaction equation
[C:1]([O:5][P:6]([C:13]([F:64])([F:63])[C:14]1[CH:62]=[CH:61][C:17]([CH2:18][C:19]([C:49]2[CH:60]=[CH:59][C:52]([C:53]([O:55][CH:56]([CH3:58])[CH3:57])=[O:54])=[CH:51][CH:50]=2)([C:40](=[O:48])[C:41]2[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=2)[CH2:20]/[CH:21]=[CH:22]/[C:23]2[CH:28]=[CH:27][C:26]([C:29]([P:32]([O:37][CH2:38][CH3:39])([O:34][CH2:35][CH3:36])=[O:33])([F:31])[F:30])=[CH:25][CH:24]=2)=[CH:16][CH:15]=1)([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:9]([O:8][P:6]([C:13]([F:64])([F:63])[C:14]1[CH:62]=[CH:61][C:17]([CH2:18][C:19]([C:49]2[CH:60]=[CH:59][C:52]([C:53]([O:55][CH:56]([CH3:57])[CH3:58])=[O:54])=[CH:51][CH:50]=2)([C:40](=[O:48])[C:41]2[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=2)[CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([P:32]([O:37][CH2:38][CH3:39])([O:34][CH2:35][CH3:36])=[O:33])([F:31])[F:30])=[CH:25][CH:24]=2)=[CH:16][CH:15]=1)([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 1

HCID 18510234HCID 18510234, compound

Product 1

HCID 18510257HCID 18510257, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of isopropyl 4-[(E)-1-{4-[[di(tert-butoxy)phosphoryl](difluro)methyl]benzyl}-4-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}-1-(4-fluorobenzoyl)-3-butenyl]benzoate in ethyl acetate was added palladium on charcoal. The mixture ws then hydrogenated on a Parr apparatus at 50 psi. The reaction mixture was filtered and evaporated to give 0.02 g of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-9e3aff92614148df9c70b3378a7120d0
Source dataset
uspto-grants-2003_06
Patent number
US06583126B2

Reaction notes

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