Hydrochloric Acid → HCID 178478295, compound

HRID 1371145Notes

Reaction equation

HRID 1371145 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:12][C:11]3=[CH:13][C:14]([C:16]4[O:17][CH:18]=[CH:19][CH:20]=4)=[N:15][C:10]3=[CH:9][N:8]=2)[CH2:3][CH2:2]1.CCOC(C)=O.[ClH:27]>CO>[ClH:27].[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:12][C:11]3=[CH:13][C:14]([C:16]4[O:17][CH:18]=[CH:19][CH:20]=4)=[N:15][C:10]3=[CH:9][N:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 178420824HCID 178420824, compound

Product 1

HCID 178478295HCID 178478295, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the method described in Example 30 by employing 2-(1-pyrrolidinylvinyl)furan (freshly prepared before use) (2.13 g, 13.1 mmol), 4,6-dichloro-5-nitropyrimidine (Aldrich Chemical Company) (2.51 g, 13.1 mmol), N,N-diisopropylethyl amine (Aldrich Chemical Company) (2.2 mL, 13.1 mmol), piperidine (Aldrich Chemical Company) (2.1 mL, 21.0 mmol), NEt3 (Aldrich Chemical Company) (2.0 mL) and SnCl2 (49 mL of a 2M solution in DMF). The residue was purified by flash chromatography on silica gel with 95:5 CHCl3:MeOH as elutant to give 162 mg (5%) of the free base as a tan colored sandy solid. 1H NMR (DMSO-d6; 400 MHz): δ 1.65 (br s, 6), 3.72 (br s, 4), 6.67 (br s, 2), 7.12 (s, 1), 7.83 (s, 1), 8.23 (s, 1), 11.27 (s, 1). MS m/z: 269 (M+1). To a solution of 2-(4-piperidylpyrrolo[4,5-d]pyrimidin-6-yl)furan (0.54 g, 1.81 mmol) in 5:1 EtOAc:MeOH (30 mL) was added 1M etheral HCl (Aldrich Chemical Company) (1.80 mL, 1.80 mmol). The precipitate was collected by filtration, washed with EtOAc (2×10 mL), ether (3×15 mL) and dried under vacuum to give 550 mg (92%) of the title compound as a beige colored solid. Mp:>280° C. 1H NMR (DMSO-d6; 400 MHz): δ 1.71 (s, 6), 4.04 (br s, 4), 6.75 (dd, 1, J=3.1, 3.3), 6.83 (s, 1), 7.39 (s, 1), 7.96 (s, 1), 8.60 (s, 1), 12.27 (s, 1), 14.32 (s, 1). MS m/z: 269 (M+1). Anal. Calcd for C15H16N4O.HCl: C, 59.11; H, 5.62; N, 18.38; Cl, 11.63. Found C, 58.84; H, 5.72; N, 18.16; Cl, 11.54.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with EtOAc (2×10 mL), ether (3×15 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-72c232e1939c4607b9d1c2d5f3ffcf77
Source dataset
uspto-grants-2003_06
Patent number
US06583154B1

Reaction notes

Loading…