Hydrochloric Acid → HCID 178479626, compound

HRID 1371150Notes

Reaction equation

HRID 1371150 reaction equation
[C:1]1([CH:7]2[NH:12][CH2:11][CH2:10][CH:9]([C:13]3[NH:18][C:17]4=[C:19]([C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=5)[CH:20]=[N:21][C:16]4=[CH:15][N:14]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC[O:30]C(C)=O.[ClH:34]>CO>[OH2:30].[ClH:34].[C:1]1([CH:7]2[NH:12][CH2:11][CH2:10][CH:9]([C:13]3[NH:18][C:17]4=[C:19]([C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=5)[CH:20]=[N:21][C:16]4=[CH:15][N:14]=3)[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 178420110HCID 178420110, compound

Product 1

HCID 178479626HCID 178479626, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the method described in Example 30 by employing (1,2-diphenylvinyl)pyrrolidine (freshly prepared before use) (1.85 g, 7.43 mmol), 4,6-dichloro-5-nitropyrimidine (Aldrich Chemical Company) (1.40 g, 7.43 mmol), N,N-diisopropylethyl amine (Aldrich Chemical Company) (1.3 mL, 7.43 mmol), piperidine (1.2 mL, 11.9 mmol), NEt3 (Aldrich Chemical Company) (2.0 mL) and SnCl2 (Aldrich Chemical Company) (22 mL of a 2M solution in DMF). The residue was purified by flash chromatography on silica gel with 95:5 CHCl3:MeOH as elutant to give 258 mg (10%) of the free base as a brown colored sandy solid. 1H NMR (DMSO-d6; 400 MHz): δ 1.66 (br s, 6), 3.75 (br s, 4), 7.19 (t, 1, J=7.3), 7.29 (t, 2, J=7.7), 7.42-7.47 (m, 7), 8.30 (s, 1), 11.38 (s, 1). MS m/z: 355 (M+1). To a solution of 6,7-diphenyl-4-piperidylpyrrolo[3,2-d]pyrimidine (0.26 g, 0.73 mmol) in 4:1 EtOAc:MeOH (30 mL) was added 1M etheral HCl (Aldrich Chemical Company) (730 mL, 0.73 mmol). The precipitate was collected by filtration, washed with ether (3×15 mL) and dried under vacuum to give 258 mg (91%) of the title compound as a beige colored solid. Mp: 266-268.5° C. 1H NMR (DMSO-d6; 400 MHz): δ 1.73 (br s, 6), 4.09 (br s, 4), 7.29 (d, 2, J=6.7), 7.37-7.44 (m, 8), 8.50 (s, 1), 12.42 (s, 1), 14.15 (s, 1). MS m/z 355 (M+1). Anal. Calcd for C23H22N4.HCl.0.25H2O: C, 69.92; H, 5.99; N, 14.18; Cl, 8.97. Found C, 69.92; H, 6.01; N, 13.86; Cl, 9.37.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ether (3×15 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-842b83b55e0e43b395854363b6b49382
Source dataset
uspto-grants-2003_06
Patent number
US06583154B1

Reaction notes

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