Hydrochloric Acid → 1-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-yl}methanamine Dihydrochloride

HRID 1371395Notes

Reaction equation

HRID 1371395 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([N:11]2[CH2:16][CH2:15][O:14][C@@H:13]([CH2:17][NH:18]C(=O)OC(C)(C)C)[CH2:12]2)[CH3:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[ClH:26].CO>O1CCOCC1>[ClH:1].[ClH:26].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([N:11]2[CH2:16][CH2:15][O:14][C@@H:13]([CH2:17][NH2:18])[CH2:12]2)[CH3:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86760345tert-Butyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate

Product 1

HCID 690592951-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-yl}methanamine Dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Intermediate 32 was treated with 4M hydrogen chloride in dioxane (15 ml) and the solution stirred for 2 h at room temperature. The solution was treated with methanol (20 ml) and concentrated in vacuo to give the title compound as an off-white solid (1.53 g).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-682c33b79d4a4dcdad9b4a77aeb42c57
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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