4-Bromophenyl isocyanate → HCID 17984749, compound

HRID 1371420Notes

Reaction equation

HRID 1371420 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Br:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 756094-Bromophenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 17984749HCID 17984749, compoundYield 76.8%

Procedure

Example 20 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-bromo-4-isocyanatobenzene (0.027 g) to give the title compound (0.033 g). LC-MS (System A): Rt 2.49 mins, Mass Spectrum m/z 472 [MH+].

Workup

  1. customExample 20 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-1fe2c15411214ce3a638fb3c17203d8a
Source dataset
uspto-grants-2007_01
Patent number
US07157457B2

Reaction notes

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