Piperazine → 8-(Piperazin-1-yl)isoquinoline

HRID 1371511Notes

Reaction equation

HRID 1371511 reaction equation
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[CH:10]=[N:9][CH:8]=[CH:7]3)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 98591348-Bromoisoquinoline

Product 1

HCID 210709608-(Piperazin-1-yl)isoquinoline

Procedure

8-(Piperazin-1-yl)isoquinoline is prepared from 8-bromoisoquinoline and piperazine using the coupling procedure as described in Step 1 of Preparation 54A to afford about 270 mg (88%). EIS-MS 214.0 M+1

Workup

  1. customto afford about 270 mg (88%)

Sources & evidence

ORD record
ord-15d1ac9c904e4d9db88ce2ad6cc92969
Source dataset
uspto-grants-2007_01
Patent number
US07157463B2

Reaction notes

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