Piperazine → 8-(1-piperazinyl)Quinoline

HRID 1371513Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[N:10]=[CH:9][CH:8]=[CH:7]3)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

Reactant 2

HCID 4837Piperazine

HCID 1401098-Bromoquinoline

Product 1

HCID 118307868-(1-piperazinyl)Quinoline

Procedure

8-(Piperazin-1-yl)quinoline is prepared from 8-bromoquinoline and piperazine as described in Step 1 of Preparation 54A to afford about 490 mg (95%). EIS-MS 207.8 (M+1).

Workup

customto afford about 490 mg (95%)

Sources & evidence

ORD record: ord-6a9a3eb341b84319b70a186d86bdea3d
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157463B2

Reaction notes

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