反应详情

Combine (3-[1,3]dioxolan-2-ylphenyl)-phenyl-methanol (2.3 g, 8.7 mmol) and sodium iodide (5.3 g, 35.0 mmol) in acetonitrile (25 ml). Add dichloromethylsilane (2.1 ml, 17.4 mmol) via syringe. After 10 min, dilute with EtOAc and wash with water, saturated sodium bicarbonate, 10% sodium thiosulfate, and then brine. Dry the organic layers (Na2SO4), filter, and concentrate to give a residue. Chromatograph the residue eluting with 9:1 hexane:EtOAc to give the title compound.

1. washwash with water, saturated sodium bicarbonate, 10% sodium thiosulfate
2. dry with materialDry the organic layers (Na2SO4)
3. filtrationfilter
4. concentrationconcentrate
5. customto give a residue
6. washChromatograph the residue eluting with 9:1 hexane