反应详情

温度

0 °C

Combine N-dibenzofuran-3-ylamine (2.0 g, 10.8 mmol), water (20 ml), and conc. hydrobromic acid (6 ml). Cool to 0° C. Add a solution of sodium nitrite (0.7 g, 10.8 mmol) in water (16 ml). After 15 minutes add the mixture above to a mixture of copper bromide (1.7 g, 12.3 mmol) in water (9.2 ml) and hydrobromic acid (4 ml). Warm to ambient temperature. After 18 hours, add water and extract with dichloromethane. Combine the organic layers and wash sequentially with distilled water and brine and then dry (Na2SO4), filter, and concentrate to give a residue. Chromatograph the residue eluting with 8:2 hexane:EtOAc to give the title compound.

1. additionAfter 15 minutes add the mixture
2. temperatureWarm to ambient temperature
3. extractionextract with dichloromethane
4. washwash sequentially with distilled water and brine
5. dry with materialdry (Na2SO4)
6. filtrationfilter
7. concentrationconcentrate
8. customto give a residue
9. washChromatograph the residue eluting with 8:2 hexane