Boron trifluoride etherate → HCID 23006211, compound

HRID 1372001Notes

Reaction equation

HRID 1372001 reaction equation
[CH:1]#[C:2][CH2:3][CH2:4][CH3:5].[Li]CCCC.[C:11]([C:15](OCC)=O)([F:14])([F:13])[F:12].B(F)(F)F.O(CC)CC.[NH2:29][NH2:30]>C1COCC1.C1C=CC=CC=1>[CH2:3]([C:4]1[NH:30][N:29]=[C:15]([C:11]([F:12])([F:13])[F:14])[CH:5]=1)[CH2:2][CH3:1]

Participants

8

Reactant 5

HCID 8000Boron trifluoride etherateHCID 9321HydrazineHCID 9794Ethyl trifluoroacetateHCID 123091-PentyneHCID 178418339Butyllithium

Product 1

HCID 23006211HCID 23006211, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following protocol H, 1-pentyne was treated with n-BuLi, CF3CO2Et and BF3-OEt2 in THF. Reaction with hydrazine in benzene under similar reaction conditions yielded title compound.

Workup

  1. customunder similar reaction conditions

Sources & evidence

ORD record
ord-57fd2d58aa524cefa9ed482bac3c0469
Source dataset
uspto-grants-2007_01
Patent number
US07157464B2

Reaction notes

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