Chlorosuccinimide → HCID 21071132, compound

HRID 1372007Notes

Reaction equation

HRID 1372007 reaction equation
[CH:1]([C:4]1[CH:8]=[C:7]([CH:9]([CH3:11])[CH3:10])[NH:6][N:5]=1)([CH3:3])[CH3:2].C1C(=O)N([Cl:19])C(=O)C1>CN(C=O)C>[Cl:19][C:8]1[C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][NH:6][C:7]=1[CH:9]([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 52552293,5-Diisopropylpyrazole

Product 1

HCID 21071132HCID 21071132, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Following protocol L, a the solution of 3,5-diisopropyl-pyrazole (0.5 g, 3.57 mmol) in DMF (10 mL) was added NCS (0.72 g, 5.3 mmol) in portions under vigorous stirring. The reaction mixture was then heated at 80° C. for 14 h and then the reaction was quenched with water. It was then extracted with ethyl acetate (2×30 mL). The combined organics were washed with brine. The organic extracts were combined and dried with Na2SO4 and finally evaporated to give the title compound as colorless oil.

Workup

  1. customthe reaction was quenched with water
  2. extractionIt was then extracted with ethyl acetate (2×30 mL)
  3. washThe combined organics were washed with brine
  4. dry with materialdried with Na2SO4
  5. customfinally evaporated

Sources & evidence

ORD record
ord-0cf25fe4cabc45a4a00f280e0530de8a
Source dataset
uspto-grants-2007_01
Patent number
US07157464B2

Reaction notes

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