Dichloromethane → 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine

HRID 1372067Notes

Reaction equation

HRID 1372067 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CCN(CC)CC.[Cl:21][CH2:22][C:23](Cl)=[O:24].C(Cl)Cl>CCCCCC.C(OCC)(=O)C>[Cl:21][CH2:22][C:23]([N:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1)=[O:24]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 974781-(4-Chlorophenyl)piperazine

Product 1

HCID 40539571-(Chloroacetyl)-4-(4-chlorophenyl)piperazine

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Protocol S was followed using 1-(4-chloro-phenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compound as a white solid.

Sources & evidence

ORD record
ord-85efcc1afeb74f9abca1f9d43b5817eb
Source dataset
uspto-grants-2007_01
Patent number
US07157464B2

Reaction notes

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