反应详情

Protocol T was followed using 5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compound. 1H NMR (400 MHz, CDCl3): 7.32–7.36 (m, 1H), 7.22–7.26 (m, 1H), 7.08 (s, 1H), 7.02–7.08 (dd, 1H), 6.96–7.2 (m, 2H), 6.86–6.92 (m, 2H), 4.3–4.4 (q, 2H), 3.52–3.58 (m, 4H), 3.05–3.25 (m, 4H), 1.3–1.42 (m, 3H). 13C NMR (400 MHz, CDCl3): 164, 130, 126.8, 126.4, 120, 118.2, 115.4, 62.3, 54, 50.5, 42, 44.5, 14.6.