反应详情

Protocol T was followed using 4-Chloro-5-phenyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 7.4–7.52 (m, 5H), 7.18–7.22 (d, 1H), 6.44–6.48 (d, 1H), 6.36–6.42 (dd, 1H), 4.72 (s, 2H), 3.86 (s, 3H), 3.5–3.78 (m, 4H), 3.1 (s, 4H). 13C NMR (400 MHz, CDCl3) 164, 156.2, 150.4, 130.5, 130, 128.5, 110, 102.2, 56, 52, 50, 44.8, 42.