反应详情

Protocol T was followed using 3,4,5-Tribromo-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 6.96–7.2 (m, 2H), 6.84–6.9 (m, 2H), 5.4 (s, 2H), 3.74–3.8 (m, 2H), 3.6–3.68 (m, 2H), 3.04–3.14 (m, 4H). 13C NMR (400 MHz, CDCl3): 164.4, 158, 156, 144.2, 128, 118.4, 118.2, 116, 100, 52.8, 50.2, 50.0, 46.0, 42.2.