反应详情

Protocol T was followed using 4-Amino-3-heptafluoropropyl-5-methyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4, Rf=0.42) afforded the title compound as colorless oil. 1H NMR (400 MHz, CDCl3); 6.88–6.94 (d, 2H), 7.22–7.26 (d, 2H), 4.98 (s, 2H), 3.64–3.82 (m, 4H), 3.1–3.22 (m, 4H), 2.98(s, 2H), 2.18 (s, 3H). MS (ES) M+H) expected=501.82, found 502.1.