Triethylamine → (R)-(-)-1-CBZ-3-pyrrolidinol

A 22-L, 3-neck, round bottom flask equipped with mechanical stirrer, thermocouple, addition funnel and nitrogen bubbler was charged with 425 g (4.88 mol) of (3R)-3-hydroxypyrrolidine, 8 L of dichloromethane, and 1 L (7.17 mol) of triethylamine. The solution was cooled to 5–10° C. with an ice bath and then 1000 g (5.86 mol) of benzyl chloroformate was added dropwise over a period of about 1.5 h keeping the reaction temperature <20° C. The reaction mixture was stirred for an additional hour in the ice bath, then the bath was removed and the reaction mixture was allowed to warm to ambient temperature overnight. The mixture was poured into a large extractor containing ˜15 L of saturated aqueous sodium bicarbonate solution. The aqueous phase was back-extracted with two 2-L portions of dichloromethane. The combined organics were dried over magnesium sulfate and concentrated to give an orange oil. The crude material was taken up in dichloromethane, applied to a 5-kg column of silica gel prepacked in 50% ethyl acetate/hexane, and eluted sequentially with 8 L of 50%, 16 L of 75%, then 100% ethyl acetate/hexane to provide the title compound as a yellow oil which crystallized upon standing.

1. additionthermocouple, addition funnel
2. temperatureThe solution was cooled to 5–10° C. with an ice bath
3. customthe reaction temperature <20° C
4. customthe bath was removed
5. additionThe mixture was poured into a large extractor
6. additioncontaining ˜15 L of saturated aqueous sodium bicarbonate solution
7. extractionThe aqueous phase was back-extracted with two 2-L portions of dichloromethane
8. dry with materialThe combined organics were dried over magnesium sulfate
9. concentrationconcentrated
10. customto give an orange oil
11. washeluted sequentially with 8 L of 50%, 16 L of 75%

ORD record

ord-d2f29e72947b4bfd9a70908391dc4418

Source dataset

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07157490B2