反应详情

THF (30 ml) and 0.25N NaOH (32 ml, 8.00 mmol) were added to methyl 2-(2-methylphenylamino)-6-benzoxazolylacetate (1.18 g, 3.98 mmol), followed by stirring at room temperature for 5 hours. The reaction mixture was poured in 1N HCl (50 ml), followed by extraction with a chloroform-methanol (5:1, 2×200 ml) mixture. The extract was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent, whereby the title compound (867 mg, 77%) was obtained as a pale yellow amorphous substance.

1. extractionfollowed by extraction with a chloroform-methanol (5:1, 2×200 ml) mixture
2. dry with materialThe extract was dried over anhydrous magnesium sulfate
3. distillationdistilled under reduced pressure
4. customto remove the solvent, whereby the title compound (867 mg, 77%)
5. customwas obtained as a pale yellow amorphous substance