反应详情

To a solution of ethyl 3-chloro-4-(1-methyl-3-indolylcarbonylamino)phenylacetate (639 mg, 1.72 mmol) in THF (17.5 mL) was added 0.25N NaOH (10.3 mL, 2.58 mmol). The resulting mixture was stirred at room temperature for 4 hours. Under ice cooling, the reaction mixture was poured in 1N HCl (15 ml). The crystals thus precipitated were collected by filtration, washed with water and dried under reduced pressure, whereby 3-chloro-4-(1-methyl-3-indolylcarbonylamino)phenylacetic acid (549 mg, 93%) was obtained as a colorless solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration
3. washwashed with water
4. customdried under reduced pressure