反应详情

After addition of 0.25N NaOH (3.75 mL, 0.93 mmol) to a solution of methyl 2-(1-methyl-3-indolyl)-6-benzoxazolylacetate (200 mg, 0.62 mmol) in THF (6.5 mL), the mixture was stirred at room temperature for 2 hours. Under ice cooling, the reaction mixture was poured in 1N HCl (10 mL). The crystals thus precipitated were collected by filtration, washed with water and dried under reduced pressure, whereby 2-(1-methyl-3-indolyl)-6-benzoxazolylacetic acid (189 mg, 99%) was obtained as a colorless solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration
3. washwashed with water
4. customdried under reduced pressure