Sodium Hydroxide → 2-(1-Methyl-3-indolyl)-6-benzoxazolylacetic acid

HRID 1372637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1372637
[OH-].[Na+].[CH3:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]2[O:14][C:15]3[CH:21]=[C:20]([CH2:22][C:23]([O:25]C)=[O:24])[CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:5]1>C1COCC1.Cl>[CH3:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]2[O:14][C:15]3[CH:21]=[C:20]([CH2:22][C:23]([OH:25])=[O:24])[CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:5]1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 58778404Methyl 2-(1-methyl-3-indolyl)-6-benzoxazolylacetate

Produkt 1

HCID 587788162-(1-Methyl-3-indolyl)-6-benzoxazolylacetic acidAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

After addition of 0.25N NaOH (3.75 mL, 0.93 mmol) to a solution of methyl 2-(1-methyl-3-indolyl)-6-benzoxazolylacetate (200 mg, 0.62 mmol) in THF (6.5 mL), the mixture was stirred at room temperature for 2 hours. Under ice cooling, the reaction mixture was poured in 1N HCl (10 mL). The crystals thus precipitated were collected by filtration, washed with water and dried under reduced pressure, whereby 2-(1-methyl-3-indolyl)-6-benzoxazolylacetic acid (189 mg, 99%) was obtained as a colorless solid.

Aufarbeitung

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-59a74e365543419082f5e85182054692
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157487B2

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