反应详情

Ethyl (3-bromo-4-((3-indolylcarbonyl)amino)phenyl)acetate (664 mg, 1.65 mmol) was dissolved in THF (17 ml). To the resulting solution was added 0.25N NaOH (10.0 ml, 2.48 mmol). After stirring at room temperature for 24 hours, the reaction mixture was poured in 1N HCl to acidify the mixture. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-bromo-4-((3-indolylcarbonyl)amino)phenyl)acetic acid (341 mg, 55%) as a brown solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure