反应详情

In THF (19 ml) was dissolved ethyl (5-chloro-2-fluoro-4-((4-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetate (762 mg, 1.87 mmol). To the resulting solution was added 0.25N NaOH (11.2 ml, 2.81 mmol) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into 1N HCl (3.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (5-chloro-2-fluoro-4-((4-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetic acid (698 mg, 99%) as a purple solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure