反应详情

To methyl (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetate (1.08 g, 3.02 mmol) were added THF (30 ml) and 0.25N NaOH (18.1 ml, 4.53 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was poured in 1N HCl (5.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid (0.99 g, 95%) as a brown solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure