反应详情

To methyl (2-(3-pyridyl)-6-benzoxazolyl)acetate (360 mg, 1.34 mmol) were added THF (8 ml) and 0.5N NaOH (8.0 ml, 4.00 mmol). The resulting mixture was stirred at room temperature for 20 hours. To the reaction mixture were added water and 1N HCl (5.0 ml, 5 mmol) to acidify the mixture, followed by extraction with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and distilled under reduced pressure to remove the solvent to give (2-(3-pyridyl)-6-benzoxazolyl)acetic acid (179 mg, 52%) as a yellow solid.

1. extractionfollowed by extraction with ethyl acetate
2. washThe extract was washed with saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. distillationdistilled under reduced pressure
5. customto remove the solvent