反应详情

Methyl 1-(4-methoxybenzyl)-3-indazolylcarboxylate (830 mg, 2.80 mmol) was dissolved in THF (22 ml). To the resulting solution was added 0.25N NaOH (22 ml, 5.60 mmol). The resulting mixture was stirred for 15 hours at room temperature. The reaction mixture was poured in 1N HCl (50 ml), followed by extraction with chloroform (2×100 ml). The extract was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent. The residue was dissolved in chloroform and hexane was added to the resulting solution until precipitation appeared. The crystals thus precipitated were collected by filtration under reduced pressure and dried for 12 hours under reduced pressure to give 1-(4-methoxybenzyl)-3-indazolylcarboxylicacid (630 mg, 80%) as a colorless amorphous substance.

1. extractionfollowed by extraction with chloroform (2×100 ml)
2. dry with materialThe extract was dried over anhydrous magnesium sulfate
3. distillationdistilled under reduced pressure
4. customto remove the solvent
5. dissolutionThe residue was dissolved in chloroform
6. additionhexane was added to the resulting solution until precipitation
7. customThe crystals thus precipitated
8. filtrationwere collected by filtration under reduced pressure
9. customdried for 12 hours under reduced pressure