Water → HCID 21072676, compound

HRID 1372878Notes

Reaction equation

HRID 1372878 reaction equation
C([O:4][CH2:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][C:25]=3[C:26]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=3)=[O:27])=[O:22])=[N:19][CH:20]=2)[CH2:10][CH2:9]1)=[O:7])(=O)C.C(=O)([O-])[O-].[K+].[K+].O>CO>[OH:4][CH2:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][C:25]=3[C:26]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=3)=[O:27])=[O:22])=[N:19][CH:20]=2)[CH2:10][CH2:9]1)=[O:7]

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 21072678HCID 21072678, compound

Product 1

HCID 21072676HCID 21072676, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[5-[4-(acetoxyacetyl)hexahydro-1,4-diazepin-1-yl]pyrazin-2-ylcarbonylamino]-5-methyl-N-(5-chloropyridin-2-yl)benzamide (Example 86, 0.22 g) in methanol (5 mL) was added potassium carbonate (0.1 g) and water (1 mL). The mixture was stirred overnight, the methanol was evaporated, and the resulting solution acidified to pH 5 with acetic acid. The solids were filtered, washed with water (2×3 mL), ether (3 mL) and dried under vacuum. Yield=0.19 g.

Workup

  1. customthe methanol was evaporated
  2. filtrationThe solids were filtered
  3. washwashed with water (2×3 mL), ether (3 mL)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-aaa737fb4a12445c9a6c5c1fa0b29db2
Source dataset
uspto-grants-2007_01
Patent number
US07160878B2

Reaction notes

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