Phthalazine-5,8-dione → HCID 21072872, compound

HRID 1372897Notes

Reaction equation

HRID 1372897 reaction equation
[CH:1]1[C:10]2[C:9](=[O:11])[CH:8]=[CH:7][C:6](=[O:12])[C:5]=2[CH:4]=[N:3][N:2]=1.[CH3:13][O:14][C:15]1[CH:24]=[CH:23][C:18]([CH2:19][N:20]=[N+:21]=[N-:22])=[CH:17][CH:16]=1>C(OCC)(=O)C>[CH3:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][N:20]2[C:7]3[C:6](=[O:12])[C:5]4[CH:4]=[N:3][N:2]=[CH:1][C:10]=4[C:9](=[O:11])[C:8]=3[N:22]=[N:21]2)=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 10057794Phthalazine-5,8-dioneHCID 109317671-(Azidomethyl)-4-methoxybenzene

Product 1

HCID 21072872HCID 21072872, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

333 mg (2.07 mmol) of phthalazin-5,8-dione (1.00 g, 6.20 mmol) and 4-methoxybenzyl azide were dissolved in 60 ml of ethyl acetate, and then refluxed overnight. The solvent was removed under reduced pressure and residue was separated and purified by using column chromatography (ethyl acetate). 415 mg of brown powder was obtained and the yield was 62%.

Workup

  1. temperaturerefluxed overnight
  2. customThe solvent was removed under reduced pressure and residue
  3. customwas separated
  4. custompurified

Sources & evidence

ORD record
ord-cc5c712c7a114d858e16174124bce768
Source dataset
uspto-grants-2007_01
Patent number
US07160884B2

Reaction notes

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