反应详情

90.0 mL (180.00 mmol) of propylmagnesium chloride (2 M in ether) are added dropwise within 30 min. to a solution of 7.00 mL (54.04 mmol) methyl anthranilate in abs. THF (70 mL) at 0° C. The mixture is stirred for 1 h at RT and then combined with 100 mL 3 M aqueous ammonium chloride solution and EtOAc. The phases are separated and the aqueous phase is exhaustively extracted with EtOAc. The combined org. phases are washed with aqueous KHCO3 and sat. aqueous NaCl and dried with sodium sulphate. The crude product is used in the next reaction step without any further purification.

1. customat 0° C
2. customThe phases are separated
3. extractionthe aqueous phase is exhaustively extracted with EtOAc
4. washphases are washed with aqueous KHCO3 and sat. aqueous NaCl
5. dry with materialdried with sodium sulphate
6. customThe crude product is used in the next reaction step without any further purification