HRID1373144

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

$结构：CCO/C(=C1\C(=O)N(C(C)=O)c2ccc(N(C)S(=O)(=O)c3ccccc3)cc21)c1ccccc1$

HCID18005732

未命名化合物

HCID22569663

未命名化合物

PRODUCTS

生成物

$结构：CN(C)CCN(c1ccc(N/C(=C2\C(=O)Nc3ccc(N(C)S(=O)(=O)c4ccccc4)cc32)c2ccccc2)cc1)S(C)(=O)=O$

HCID178483746

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 1f from 350 mg (0.73 mmol) of (Z)-1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-methyl-N-phenylsulphonyl-amino)-2-indolinone and 257 mg (1 mmol) of 4-[N-(2-dimethylamino-ethyl)-N-methylsulphonyl-amino]-aniline in DMF and subsequent treatment with sodium hydroxide solution.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67bd305621074c63895cc79d08de0b36
来源数据集: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07160901B2
来源说明: uspto-grants-2007_01

反应 SMILES

C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N:13]([CH3:23])[S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])=[CH:10][CH:11]=2)/[C:6](=[C:24](/OCC)\[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)/[C:5]1=[O:34])(=O)C.[CH3:35][N:36]([CH3:51])[CH2:37][CH2:38][N:39]([C:44]1[CH:50]=[CH:49][C:47]([NH2:48])=[CH:46][CH:45]=1)[S:40]([CH3:43])(=[O:42])=[O:41].[OH-].[Na+]>CN(C=O)C>[CH3:35][N:36]([CH3:51])[CH2:37][CH2:38][N:39]([C:44]1[CH:45]=[CH:46][C:47]([NH:48]/[C:24](=[C:6]2\[C:5](=[O:34])[NH:4][C:12]3[C:7]\2=[CH:8][C:9]([N:13]([CH3:23])[S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:10][CH:11]=3)/[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[CH:49][CH:50]=1)[S:40]([CH3:43])(=[O:42])=[O:41]