3-Amino-1-propanol → N~1~-(3-Hydroxypropyl)ethanediamide

HRID 1373148Notes

Reaction equation

HRID 1373148 reaction equation
O[CH2:2][CH2:3][NH:4][C:5](=[O:9])[C:6]([NH2:8])=[O:7].NCC[CH2:13][OH:14]>>[OH:14][CH2:13][CH2:2][CH2:3][NH:4][C:5](=[O:9])[C:6]([NH2:8])=[O:7]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 5249043N-(2-hydroxyethyl)oxalamide

Product 1

HCID 14935787N~1~-(3-Hydroxypropyl)ethanediamideYield 75%

Procedure

Prepared as in Intermediate 3, using 3-aminopropanol to give the title compound as a white powder (1.15 g, 75%); NMR [(CD3)2SO] 1.6 (2H, m), 3.18 (2H, m), 3.42 (2H, m), 4.47 (1H, t), 7.73 (1H, br s), 8.0 (1H, br s), and 8.63 (1H, t).

Sources & evidence

ORD record
ord-95bbbdf359e249be9cc1fc636739ee1a
Source dataset
uspto-grants-2007_01
Patent number
US07160907B2

Reaction notes

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