Diisopropylethylamine → HCID 21074273, compound

HRID 1373166Notes

Reaction equation

HRID 1373166 reaction equation
[NH:1]1[CH2:5][C:4](=[O:6])[NH:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1F.C(N(C(C)C)CC)(C)C>CN(C=O)C>[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1[N:1]1[CH2:5][C:4](=[O:6])[NH:3][CH2:2]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 15020634-ImidazolidinoneHCID 27827931,2,3-Trifluoro-5-nitrobenzene

Product 1

HCID 21074273HCID 21074273, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4-imidazolidinone (9.5 g, 110.5 mmol), 3,4,5-trifluoronitrobenzene (1 eq) and diisopropyl ethylamine (28.6 mL, 165 mmol) in dry DMF (80 mL) was heated to 60° C. overnight under argon. The reaction mixture was allowed to cool to room temperature and ice pieces were added. The solid formed was filtered and washed with water. The solid was air dried to yield the nitro compound as yellow crystals.

Workup

  1. additionice pieces were added
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-bac4f14b348c48019704e640aa2871ef
Source dataset
uspto-grants-2007_01
Patent number
US07160912B2

Reaction notes

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