反应详情

温度

100 °C

A mixture of 4-chloro-2-fluoronitrobenzene (7.0 g, 40 mmols), N-tert-butoxycarbonyl-3-hydroxyphenethylamine (9.5 g, 40 mmols), potassium carbonate (5.5 g, 40 mmols) and N,N-dimethylformamide (100 ml) was stirred at 100° C. for 12 hours. The reaction mixture was cooled, then poured into water, and extracted with ethyl acetate. The extract was washed with water, and then dried with anhydrous magnesium sulfate, and the solvent was evaporated away. The residue was purified through silica gel column chromatography to give an oil of tert-butyl 2-[3-(5-chloro-2-nitrophenoxy)phenyl]ethylcarbamate (15.2 g, 96.6%).

1. temperatureThe reaction mixture was cooled
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried with anhydrous magnesium sulfate
5. customthe solvent was evaporated away
6. customThe residue was purified through silica gel column chromatography