Toluene → HCID 21361290, compound

HRID 1373340Notes

Reaction equation

[CH2:1]([C:3]1([CH2:21][CH3:22])[CH2:8][CH:7]([OH:9])[CH2:6][C:5]([CH3:11])([CH3:10])[N:4]1[O:12][CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:14])[CH3:2].C(N([CH2:28][CH3:29])CC)C.[C:30]1([CH3:36])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:21]([C:3]1([CH2:1][CH3:2])[CH2:8][CH:7]([O:9][C:7](=[O:9])[CH2:6][CH2:5][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:30][CH2:36][CH2:28][CH3:29])[CH2:6][C:5]([CH3:11])([CH3:10])[N:4]1[O:12][CH:13]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH3:14])[CH3:22]

Participants

Reactant 3

HCID 1140Toluene

HCID 8471Triethylamine

HCID 22341826HCID 22341826, compound2×

Product 1

HCID 21361290HCID 21361290, compoundYield 91%

Procedure

In analogy to example 1 were reacted 6.1 g (2 mmol) of 2,2-diethyl-6,6-dimethyl-1-(1-phenyl-ethoxy)-piperidin-4-ol (prepared as described in GB 2335190, compound 110) with 4.38 g (2 mmol) of lauroyl chloride chloride and 2.02 g (2 mmol) of triethylamine in toluene to give 8.9 g (91%) dodecanoic acid 2,2-diethyl-6,6-dimethyl-1-(1-phenyl-ethoxy)-piperidin-4-yl ester as yellowish liquid.

Sources & evidence

ORD record: ord-b179ba9e3c0e45cbb2aace519d54a02c
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07160966B2

Reaction notes

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