反应详情

15 mmol of the product obtained in Step B, 16 mmol of vinyltributyltin and 0.43 mmol of tetrakis(triphenylphosphine)palladium are heated for 3 hours at 110° C., with stirring, in 30 ml of N-methylpyrrolidinone. After removal of the solvent by evaporation, the residue is taken up in 20 ml of dichloromethane and treated with an aqueous 10% potassium fluoride solution. Extraction, concentration under reduced pressure and chromatography on silica gel yield the pure title product.

1. customAfter removal of the solvent
2. customby evaporation
3. additiontreated with an aqueous 10% potassium fluoride solution
4. extractionExtraction, concentration under reduced pressure and chromatography on silica gel