Trifluoroacetic acid → HCID 21075351, compound

HRID 1373700Notes

Reaction equation

HRID 1373700 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:40]=[CH:39][C:18]([C:19]([NH:21][C:22]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:23]=3[C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=3)=[O:25])=[O:20])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl.C1(OC)C=CC=CC=1>[F:38][C:35]1[CH:36]=[CH:37][C:22]([NH:21][C:19](=[O:20])[C:18]2[CH:17]=[CH:16][C:15]([N:11]3[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]3)=[CH:40][CH:39]=2)=[C:23]([CH:34]=1)[C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=1)=[O:25]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21075308HCID 21075308, compound

Product 1

HCID 21075351HCID 21075351, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 7519AnisoleSolvent

Procedure

To a suspension of 2-[4-(4-t-butoxycarbonylhexahydro-1,4-diazepin-1-yl)benzoylamino]-5-fluoro-N-(5-chloropyridin-2-yl)benzamide (Example P1, 0.59 g) in methylene chloride (3 mL) and anisole (1 mL) was added trifluoroacetic acid (3 mL) dropwise. The mixture was stirred overnight at room temperature before the solvent was evaporated. The residue was purified by using an SCX column. Yield 0.337 g.

Workup

  1. customwas evaporated
  2. customThe residue was purified

Sources & evidence

ORD record
ord-aaed817647474a258bf1278c36de5235
Source dataset
uspto-grants-2007_01
Patent number
US07163938B2

Reaction notes

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