反应详情

A solution of N-isopropyl(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)amine (1.84 g, 7.66 mmol) dissolved in 50 mL of 1,2-dichloroethane was treated with MCPBA (77% max., 2.36 g, 9.58 mmol). After stirring for 3 h, the reaction mixture was treated with 2% Na2CO3 solution and extracted into CH2Cl2. The organic portion was washed with saturated 2% Na2CO3 solution, H2O and brine. The organic portion was dried over Na2SO4, filtered and concentrated to give N-isopropyl(2-methyl-5-oxido-1H-imidazo[4,5-c]quinolin-1-yl)amine (1.95 g) as a light orange solid.

1. extractionextracted into CH2Cl2
2. washThe organic portion was washed with saturated 2% Na2CO3 solution, H2O and brine
3. dry with materialThe organic portion was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated