Lithium Hydroxide → HCID 23714172, compound

HRID 1374259Notes

Reaction equation

HRID 1374259 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][N:16]=2)[C:10]([O:12]C)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Li+:18]>C1COCC1>[C:1]1([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][N:16]=2)[C:10]([O-:12])=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[Li+:18]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 12183945Methyl 2-Phenylisonicotinate

Product 1

HCID 23714172HCID 23714172, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Preparation H1, Step 4: A solution of methyl 2-phenylisonicotinate, N-oxide (397 mg, 1.73 mmol) in THF (6 mL) was treated with 0.5 N aqueous lithium hydroxide (3.65 mL, 1.81 mmol), and the mixture was stirred overnight. The THF was stripped, and the aqueous solution was freeze dried to yield lithium 2-phenylisonicotinate, N-oxide a colorless glass, which was used as-is in the next step.

Workup

  1. customPreparation H1, Step 4
  2. customdried

Sources & evidence

ORD record
ord-58721df66ae24e1eb7bf75a8177abb32
Source dataset
uspto-grants-2007_01
Patent number
US07163937B2

Reaction notes

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