Diisopropylethylamine → HCID 69413866, compound

HRID 1374544Notes

Reaction equation

HRID 1374544 reaction equation
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]2[CH2:7][NH:8][CH2:9][CH2:10][C@@:11]34[C@@H:16]([O:17][C:4]=1[C:5]=23)[CH2:15][C@@H:14]([OH:18])[CH:13]=[CH:12]4.I[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([CH:29]1[CH2:38][C:37]2[C:32]3=[C:33]([CH2:39][C:40](=[O:41])[N:31]3[CH2:30]1)[CH:34]=[CH:35][CH:36]=2)=[O:28].C(N(C(C)C)C(C)C)C>C(Cl)(Cl)Cl>[OH:18][C@H:14]1[CH:13]=[CH:12][C@@:11]23[CH2:10][CH2:9][N:8]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([CH:29]4[CH2:38][C:37]5[C:32]6=[C:33]([CH2:39][C:40](=[O:41])[N:31]6[CH2:30]4)[CH:34]=[CH:35][CH:36]=5)=[O:28])[CH2:7][C:6]4=[C:5]2[C:4](=[C:3]([O:2][CH3:1])[CH:20]=[CH:19]4)[O:17][C@H:16]3[CH2:15]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 9838394N-DesmethylgalanthamineHCID 21076643HCID 21076643, compound

Product 1

HCID 69413866HCID 69413866, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Norgalanthamine (1.13 g, 1.64 mmol), 5-(6-iodo-1-oxohexyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one (1.50 g, 3.75 mmol) and N-ethyldiisopropylamine (1.46 g, 11.3 mmol) are stirred in absolute chloroform (20 ml) for 54 hours at boiling temperature.

Sources & evidence

ORD record
ord-5d0f4817c29a4cabbe103870860f63ac
Source dataset
uspto-grants-2007_01
Patent number
US07166588B2

Reaction notes

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