Potassium Cyanide → 2-Bromo-4-methoxy-5-(1-methylethoxy)benzene Acetonitrile

HRID 1374547Notes

Reaction equation

HRID 1374547 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH2:14]Cl.[C-:16]#[N:17].[K+]>CS(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH2:14][C:16]#[N:17]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 15514470HCID 15514470, compound

Product 1

HCID 118221562-Bromo-4-methoxy-5-(1-methylethoxy)benzene Acetonitrile

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1-Bromo-2-(chloromethyl)-5-methoxy-4-(1-methylethoxy)benzene (7.00 g, 23.8 mmol) and potassium cyanide (1.70 g, 26.1 mmol, freshly ground) are stirred in absolute DMSO (70 ml) for 12 hours at room temperature.

Sources & evidence

ORD record
ord-31349d0fcb8b4b29a31ea9c10970201f
Source dataset
uspto-grants-2007_01
Patent number
US07166588B2

Reaction notes

Loading…