tert-butyl N-[(2-chloro-5-nitrophenyl)methyl]carbamate → Tert-butyl (5-amino-2-chlorobenzyl)carbamate

HRID 1374640Notes

Reaction equation

HRID 1374640 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([N+:17]([O-])=O)[CH:13]=[CH:14][C:15]=1[Cl:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pt]>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:13]=[CH:14][C:15]=1[Cl:16])[NH2:17])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21077620tert-butyl N-[(2-chloro-5-nitrophenyl)methyl]carbamate

Product 1

HCID 21077619Tert-butyl (5-amino-2-chlorobenzyl)carbamate

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

Prepared from 3-(tert.butyloxycarbonylaminomethyl)-4-chloro-nitrobenzene by hydrogenation in methanol at ambient temperature in the presence of platinum on charcoal, melting point: 75–77° C.

Sources & evidence

ORD record
ord-c357a77e43484c8b8c8b986ae6c1f80f
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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