tert-Butyl (2-(3-nitrophenoxy)ethyl)carbamate → tert-butyl N-[2-(3-aminophenoxy)ethyl]carbamate

HRID 1374641Notes

Reaction equation

HRID 1374641 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([N+:18]([O-])=O)[CH:15]=[CH:16][CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pt]>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:15]=[CH:16][CH:17]=1)[NH2:18])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21077618tert-Butyl (2-(3-nitrophenoxy)ethyl)carbamate

Product 1

HCID 11557882tert-butyl N-[2-(3-aminophenoxy)ethyl]carbamate

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

Prepared from 3-[2-(tert.butyloxycarbonylamino)ethoxy]-nitrobenzene by hydrogenation in methanol at ambient temperature in the presence of platinum/charcoal, Rf value: 0.42 (silica gel; petroleum ether/ethyl acetate=1:1)

Sources & evidence

ORD record
ord-c97434c57e6d4d90ab2ea25a1a786a7f
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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