Phosphorus oxychloride → 4-Chloro-2-(methylthio)-5-phenylpyrimidine

HRID 1374642Notes

Reaction equation

HRID 1374642 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7](O)[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][N:4]=1.P(Cl)(Cl)([Cl:18])=O>>[CH3:1][S:2][C:3]1[N:8]=[C:7]([Cl:18])[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178503405HCID 178503405, compound

Product 1

HCID 110209004-Chloro-2-(methylthio)-5-phenylpyrimidine

Procedure

Prepared from 2-methylsulphenyl-4-hydroxy-5-phenyl-pyrimidine by reacting with phosphorus oxychloride at reflux temperature, melting point: 99° C.

Workup

  1. temperatureat reflux temperature, melting point: 99° C.

Sources & evidence

ORD record
ord-5d2ea9fe1d664d15b2251f51cf780d22
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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