Ammonia → HCID 21077592, compound

HRID 1374649Notes

Reaction equation

HRID 1374649 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7](Cl)[C:6]([F:10])=[CH:5][N:4]=1.[CH3:11][NH2:12].C(Cl)Cl.CO.N>C(O)C>[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:12][CH3:11])[C:6]([F:10])=[CH:5][N:4]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 6329MethylamineHCID 157092984-Chloro-5-fluoro-2-(methylsulfanyl)pyrimidineHCID 21226129Dichloromethane methanol

Product 1

HCID 21077592HCID 21077592, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared from 2-methylsulphenyl-4-chloro-5-fluoro-pyrimidine by reacting with methylamine in ethanol at 100° C., Rf value: 0.53 (silica gel; methylene chloride/methanol/conc. aqueous ammonia=20:1:0.1)

Sources & evidence

ORD record
ord-8c1dd1ec030548ec9ef91a43a4b1c6a1
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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